curcumin promotes lung cancer

Curcumin interrupts HIF-1α expression at protein levels, promotes HIF-1α degradation, reverse DDP resistance and sensitizing DDP efficiency in human lung adenocarcinoma A549/DDP cells. Epub 2015 Sep 8. COVID-19 is an emerging, rapidly evolving situation. PY - 2012/1/1. During the past decade, extensive investigations have revealed curcumin sensitized various chemotherapeutic agents in human breast, colon, pancreas, gastric, liver, brain and hematological malignant disorders in vivo and in vitro. A clinical trial was conducted to find a dose of curcumin in combination with chemotherapy in metastatic breast cancer. The purpose of the present study was to identify a miRNA-mediated mechanism which plays a role in the anti-cancer … Breast cancer stem cells are an important cause of radiotherapy resistance in the clinical treatment of breast cancer patients. Epub 2018 May 11. Clinical trials are research studies that involve people. Previously, we have shown that NTHi-induced COPD-like airway inflammation promotes lung cancer in an airway conditional K-ras-induced mouse model. An abundance of animal and basic lab studies show curcumin’s potential against lung cancer. Oxymatrine inhibits the development of non-small cell lung cancer through miR-367-3p upregulation and target gene. 2015;357:196-205 133. Lung cancer is responsible for over one million deaths worldwide each year. These results demonstrate that curcumin induces A549 cell apoptosis through a miRNA pathway. Curcumin as an Adjunct Therapy and microRNA Modulator in Breast Cancer.  |  Cancer letters. Curcumin, a yellow pigment derived from Curcuma longa Linn, has been favored by the Eastern as dietary ingredients for centuries. Y1 - 2012/1/1. ... Functional studies showed miR-192-5p/215 were putative tumor suppressors in non-small cell lung cancer. There are some herbs/spices/etc that apparently mess with hormones - something breast cancer survivors need to know. 132. Crown Copyright © 2012. 2020 Aug 3;61(10):9. doi: 10.1167/iovs.61.10.9. Approximately 80% of the disease may be attributed to non-small cell lung cancer (NSCLC) ().Due to the limitations of early diagnostic techniques and the lack of early specific clinical manifestations, 70–80% of patients are … HIF-1α in A549/DDP cells was found to be overexpressed at both mRNA and protein levels together with a poor response to DDP. Curcumin effect on cancer cells' multidrug resistance: An update. Prevention and treatment information (HHS). Lung squamous cell carcinoma (LSCC) is a common histological lung cancer subtype, but unlike lung adenocarcinoma, limited therapeutic options are available for treatment. Accumulating evidence shows that curcumin, a natural product, has a potent anticancer effect on a variety of cancer cell types, such as leukemia, breast cancer, prostate cancer, and pancreatic cancer. Since 1987, the National Cancer Institute (NCI) has tested more than 1,000 different potential agents for chemopreventive activity, of which only about 40 promising agents were moved to clinical trials ().Curcumin, present in the Indian spice “haldi”, is 1 such agent that is currently under clinical investigation for cancer chemoprevention. 2020 Jul;34:101571. doi: 10.1016/j.redox.2020.101571. Oxid Med Cell Longev. Yu Q, Luo J, Zhang J, Chen Y, Chen K, Lin J, Sun S, Lin X. microRNA-222-Mediated VHL Downregulation Facilitates Retinoblastoma Chemoresistance by Increasing HIF1α Expression. Curcumin: updated molecular mechanisms and intervention targets in human lung cancer. Curcumin has been reported to have an antitumor effect by inducing apoptosis and suppressing growth of tumor cells. Curcumin suppresses cancer-promoting transcription factor proteins, including those found in 50% of lung cancers. We proposed for the first time that curcumin combined with glucose nanogold particles (Glu-GNPs) targeted breast cancer stem … Curcumin promotes apoptosis by activating the p53-miR-192-5p/215-XIAP pathway in non-small cell lung cancer. 2020 Jul 18;2020:3656419. doi: 10.1155/2020/3656419. Among all malignant tumors, lung cancer turns out to be of the highest incidence rate and the leading cause of cancer mortality, which is subsequently followed by female breast cancer and prostate cancer (Bray et al., 2018). Likewise, the compound is shown to inhibit the growth of prostate cancer and induce cell death in chronic lymphocytic leukemia. Int J Mol Sci. 2010a,b). Curcumin and OPCs cooperatively inhibit cellular growth in colorectal cancer cells. 2021 Feb 10. doi: 10.1007/s12094-020-02531-3. Lung squamous cell carcinoma (LSCC) is a common histological lung cancer subtype, but unlike lung adenocarcinoma, limited therapeutic options are available for treatment. The miRNA-186* functions by overexpression or inhibition were investigated using biological assays in A549 cells. Curcumin induces apoptosis in lung cancer cells at multiple stages of the mitochondrial cascade. Our findings shed light on drug resistant reversing effect of curcumin in lung cancer cells by inhibiting HIF-1α expression and activating caspase-3. Curcumin, the active component of turmeric, has been shown to protect against carcinogenesis and prevent tumor development.  |  Several pathways and specific targets including NF-κB, STAT3, COX-2, Akt and multidrug resistant protein have been identified to facilitate curcumin as a chemosensitizer. Author links open overlay panel Mingxiang Ye a b c 1 Jin Zhang d 1 Jiän Zhang b c Qing Miao e f Libo Yao b c Jian Zhang a. Introduction. Lung cancer is a malignant tumor with the highest morbidity and mortality worldwide, and its incidence is on the increase. Depending on the stage and the tumor ’s aggressiv eness, the five-year Curcumin reverses cis-platin resistance and promotes human lung adenocarcinoma A549/DDP cell apoptosis through HIF-1α and caspase-3 mechanisms. Combined curcumin and DDP treatment markedly inhibited A549/DDP cells proliferation, reversed DDP resistance and triggered apoptotic death by promoting HIF-1α degradation and activating caspase-3, respectively. Curcumin, a natural compound, may have anticancer effects in various cancer cells, but how it may be used to treat LSCC has not been well studied. These factors contribute to genemutations, cell cycle abnormalities and loss of the control ofepigenetic modification, inducing alterations in a variety ofsignaling pathways, such as phosphoinositide 3-kinase(PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR),RAS/RAF/mitogen-activated protein kinase (MA… Would you like email updates of new search results? 2020 Jun 4;25(11):2621. doi: 10.3390/molecules25112621. Asiatic Acid (AA) Sensitizes Multidrug-Resistant Human Lung Adenocarcinoma A549/DDP Cells to Cisplatin (DDP) via Downregulation of P-Glycoprotein (MDR1) and Its Targets. Curcumin promotes apoptosis in human lung adenocarcinoma cells through miR-186* signaling pathway.  |  Previously, we have shown that NTHi-induced COPD-like airway inflammation promotes lung cancer in an airway conditional K-ras-induced mouse model.

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